The aim of this study was to verify the moderating role of openness to experience in the relationship between negative workplace behaviors and mental health variables. The cross-sectional survey sample was 659. The moderating role of openness to experience was confirmed. Despite the expectations, low rather than openness to experience, played a protective role against intense negative behaviors. Possible explanations for this result are mainly based on the properties of the stressor being tested. Implications for further research on the role of openness to experience are presented in the later sections of the study.