Objectives: The purpose of this study was to examine whether wisdom is a mediator in the relation-ships between religious meaning system and social support among older adults. According to the theory of gerotranscendence, associations of religiousness and social support are complex and sug- gest the existence of wisdom in their internal structures. Method: The study included 466 persons aged 50–75. Three measures were used: Religious Meaning System Scale (RMSS), Three-Dimensional Wisdom Scale (3D-WS) and Berlin Social Support Scales (BSSS). Results: The analyses allowed for a partial verification of the hypothesis that wisdom is a mediator in the relationship between the religious meaning system and the multidimensional social support in late adulthood. It was confirmed that wisdom mediates the relationship between the religious meaning system and three out of the five dimensions of social support (perceived available support, actually received support and protective buffering support). Conclusion: These findings suggest that wisdom is an important element of religious meaning system and social support that is used by people as a part of their maturing into gerotranscendence to cope with life’s difficulties and challenges.