The current study investigated the relationship between depression, fear of death, and coronavirus anxiety as a potential mediator of this relationship among adults in the second half of life. Longitudinal studies were carried out with three measurements on a sample of 197 people from Poland aged 50 to 80 (M = 65.88; SD = 5.89). The following psychological methods were used: Patient Health Questionnaire (PHQ-9), Coronavirus Anxiety Scale (CAS), and Death Attitude Profile-Revised (DAP-R). The mediation analysis with bias-corrected bootstrapping method confirmed that the relation between depression and fear of death is mediated by coronavirus anxiety. These findings suggest that coronavirus anxiety is an important element of depression.