The European Union’s New Green Deal generates changes in the socio-economic development of regions. An element of this change is the transformation of the regional profiles of the energy portfolio towards more pro ecological ones. The aim of this article is to identify the conditions and reasons for the transformation of the energy portfolio of the Eastern Poland macroregion, and to define the directions of the energy portfolio evolution caused by the need to implement the goals of the European Green Deal by 2030, in order to consequently develop the forecast energy portfolio for the Eastern Poland macroregion. It has been assumed that the energy transformation of the Eastern Poland macroregion will be implemented through gradual transformation of the energy portfolio towards dispersed sources of local and civic energy. The research is based on both qualitative and quantitative approaches. The qualitative research was carried out on the basis of the diagnostic survey method with the use of the proprietary questionnaire as well as with the analysis of the content of strategic documents of the voivodships included in the Eastern Poland macroregion. The basis for the preparation of research questions was the extended PEST method which stands for: political, economic, socio-cultural, technological. Research efforts were focused on developing an energy portfolio for the region using the assumptions of the Boston consulting group matrix (a strategic planning tool). The originality of the conducted research consists in the adaptation of the BCG matrix to the development of the forecast energy portfolio and the preparation of a proposal for the aggregated energy portfolio of the Eastern Poland macroregion. The obtained results indicate that the macroregion’s energy portfolio is diversified, though with the key significance of conventional sources. It is predicted that by 2030, the following sources will change their positions within the portfolio for the Eastern Poland macroregion: solar energy, wind energy and bioenergy. However, it will retain the character of a “youth wallet”.