This study focuses on how start-ups use machine learning technology to create and appropriate value. A firm’s use of machine learning can activate data network effects. These data network effects can then create perceived value for users. This study examines the interaction between the activation of data network effects by start-ups and the value that they are able to create and appropriate based on their business model. A neo-configurational approach built on fuzzy-set qualitative comparative analysis (fsQCA) explores how the design of a firm’s business model interacts with various aspects to explain value creation and appropriation using machine learning. The study uses a sample of 122 European start-ups created between 2019 and 2022. It explores the system of interactions between business model value drivers and value creation factors under the theory of data network effects. The findings show that start-ups primarily activate the efficiency and novelty elements of value creation and value capture.